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However, in another study, acetyl-l-carnitine therapy (50 mg/kg, i.p., 6 weeks) positively impacted the regeneration of unmyelinated fibres in the sciatic nerve based on a stereological analysis of myelinated/unmyelinated axon numbers, surface area, myelin thickness, and the myelin thickness-to-axon diameter ratio [45]

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[Google Scholar] 45.Coindre J.M., Terrier P., Guillou L., Le Doussal V., Collin F., Ranchre D., Sastre X., Vilain M.O., Bonichon F., NGuyen Bui B

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Figure 9 3.8 Proposed substrate recognition and enzyme mechanism of MSA-DH The potential substrate binding site of MSA-DH was explored by superimposing the three-dimensional structure of human succinic semialdehyde dehydrogenase in complex with its substrate (PDB ID: 2W8Q) (Kim et al., 2009) (Supplementary Figure S1)