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PMCID: PMC6760402

Structurally, Dihexa is derived from angiotensin IV a naturally occurring peptide involved in brain function but has been chemically modified to dramatically enhance its potency and its ability to penetrate the blood-brain barrier

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Acknowledgments We would like to thank Mr Ken Sharpe, Statistician, Statistical Consulting Centre, Richard Berry Building, University of Melbourne, Parkville, VIC 3052, Australia, for his help with the statistical analysis

Discovery and Characterization Pickart and Thaler (1973) first isolated GHK from human plasma and characterized its copper-binding properties