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Last modified on: 8 September 2017

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It works by encouraging production of lighter melanin pigment (pheomelanin) over its darker counterpart (eumalanin)

L., Hey-Mogensen M., Brand M

However, environmental stimuli such as tumor microenvironment or tissue-resident cells may polarize M1 to M2 macrophages (Weagel et al

If we can prevent antibody formation, it has been shown that infusion reactions are dramatically decreased, and the effectiveness of pegloticase is also much better maintained