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Control of the activity of mitochondrial enzymes by reversible lysine acetylation The mitochondrial presence of several nicotinamide adenine nucleotide (NAD + )-dependent deacetylase silent information regulators (sirtuins, SIRT3, 4, and 5) recently has been described [146148]

Succinic semialdehyde (4-oxobutanoate) acts as a suitable substrate analog` as this molecule only lacks the 3-hydroxy group of MSA (3-hydroxy-4-oxobutanoate) which could be added in silico

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In studies which only additional Se was added to experimental groups, the findings were also variable