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Nor-epinephrine, a major catecholamine that promotes adipocyte lipolysis (83, 84), is released in response to cold stimulation from terminal neurons that innervate fat cells (83) to mediate non-shivering thermogenesis (85-87) through the activation of -adrenergic receptors (-ARs)

Transcription factors with the most connections to other genes included EPAS1 (also known as HIF-2), KLF13, TAL1, TBX3, GATA2, and BCL11A (Additional file 4)

They note that they experience increased energy, improved mood, and an overall better sense of well-being

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Indeed, when recovery took place after internalization, resensitization was sensitive to recycling disruption by monensin [70]