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These researchers were not the first to suggest that an inadequacy of nutrients was the cause of pernicious anemia, but their particular input was a carefully designed intervention in well-characterized pernicious anemia patients, of a special diet containing large amounts of liver

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For researchers working in this area, the gap between animal model success and human trial completion represents both frustration and opportunity

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In AS, TSA inhibits NF-B or the NLRP3 inflammasome, reducing the release of inflammatory cytokines (TNF- and IL-1), thereby alleviating their inhibitory effect on the PI3K/AKT pathway (99)