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At present, it is merely a theoretical framework for promoting further research and discussion, and should not be used as a basis for clinical decision-making

found that circ_0001273, as a cancer-promoting factor that upregulates SLC1A5 expression by binding to miR-622, which increases Gln uptake by tumor cells, consequently enhancing tumor growth and inhibiting cell apoptosis (57)

It is yet to be ascertained if an increase in the iron level is the only factor that results in pathological arthropathies in patients suffering from OA

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