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The dose should not be repeated more frequently than every four hours and not more than three times in any 24 hours

[8] Where serum B12 is borderline or normal but deficiency is still suspected clinically, measurement of methylmalonic acid (MMA) or homocysteine may provide additional diagnostic information where available

Do not expect visible changes yet

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Based on these observations, Gregorio Weber pointed out in 1975: From these results it can be definitely concluded that the time-average structure observed by X-ray diffraction is something of an abstraction, since it is not itself widelyor even sparselyrepresented at any given time in the population of molecules Indeed the protein molecule model resulting from the X-ray crystallographic observations is a platonic protein, well removed in its perfection from the kicking and screaming stochastic molecule that we infer must exist in solution

That's why you wrote a bit about it