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Long-term Administration of Ranolazine Attenuates Diastolic Dysfunction and Adverse Myocardial Remodeling in a Model of Heart Failure with Preserved Ejection Fraction

Although both studies were terminated early due to long-term preclinical hepatotoxicity

TMAO promotes atherosclerosis and is associated with platelet hyperreactivity and inflammation, which are in turn associated with the development of stroke and its secondary consequences
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In a classic IR model with the mice exposed to in situ ischemia for 1 h and reperfusion for 6 h, Wang et al
