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At the local level, the asthma-related changes include disturbances in the balance of Th1/Th2 pro- and anti-inflammatory cytokines, an increased cellular influx into the bronchi, chronic oxidative stress, and airway hyperreactivity

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There have been several documented cases of patients with Parkinson's disease in the absence of Lewy pathology, who have parkin-related disease and in some cases a mutation in the LRRK2 gene

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