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Thus, timing also holds significance in optimizing effectiveness

In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

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Use a 90-degree angle when there is adequate tissue depth and no pinch is needed

doi: 10.1126/science.72.1855.75