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Niacinamide (vitamin B3) has been added to some compounded tirzepatide formulations as well

As the prevalence of obesity continues to rise and the use of modern obesity therapies including bariatric surgery and incretin-based agents expands, it becomes increasingly important to delineate the distinct reproductive effects of these interventions [8]

Additionally, GLP-1 receptor activation may influence hepatic metabolism, though the precise mechanisms remain under investigation

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doi: 10.1016/j.cpcardiol.2024.102489

The risk is not necessarily that tirzepatide is definitively harmful to infants, but rather that no adequate human studies exist to confirm safety margins or identify rare adverse effects