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However, a larger follow-up pivotal trial, known as METAOD006 (or OPTIONS), enrolled a bigger cohort and failed to replicate statistically significant weight loss, leading the sponsoring company, Metabolic Pharmaceuticals, to halt the formal drug-development program in 2007
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On the sixth day, we removed the platform and recorded the times that the mouse crossed the quadrant in which the platform was located in 60 s [19]
