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By contrast, serine itself is an allosteric inhibitor of PHGDH, and this allosteric inhibition can spontaneously disappear at low serine levels (Sugimoto and Pizer, 1968)

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Fitzpatrick A.M., Holguin F., Teague W.G., Brown L.A

These mutations cause the inactivation of AR due to mutations conferring resistance to circulating testosterone, with more than 400 different AR mutations reported