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Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases

Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

Flooding often coincides with other environmental stresses such as salinity, temperature extremes, and heavy metals, leading to complex interactions that can be antagonistic, additive, or synergistic

Liposomes containing DOX showed better drug release and enhanced cytotoxicity in VCR-resistant human leukemia cell lines (408) and in drug-resistant brain tumors in rats (409)

2016;167:13391353.e1321

Our screening method should be useful for screening many different enzyme inhibitors