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The net impact of these changes on inflammation is unclear, but our results suggest that circadian misalignment in healthy participants impacts circulating pro- and anti- inflammatory proteins, but does not clearly increase pro-inflammatory processes, although the increased IL-10 may represent a counter-regulatory response to increased TNF- levels

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Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures

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