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Whats more, these studies have never been independently replicated (61)

In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

Analysis of the downstream mediators of toll-like receptor 3-induced apoptosis in labial salivary glands in patients with Sjgrens syndrome

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However, the addition of -tocopherol and ascorbic acid was not associated with a greater histological or biochemical improvement as compared to placebo [65,66]