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10.1603/0022-0493-94.2.524 27 CaiT.ZhangY.LiuY.DengX.HeS.LiJ.et al (2021)

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, et al

Schaap FG, Trauner M, Jansen PL

The results validated the superiority of curcumin encapsulated into PLAPEG NPs over both polymer NPs itself and free curcumin in elevating the level of plasma insulin, decreasing the level of plasma glucose, protecting the liver from inammation, and ameliorating hepatic functioning in STZ-induced diabetic rats

Our study indicates that inability of Syn variants to refold into their native inert state likely causes chaperones to remain bound for extended periods beyond their biological timescale, thereby compromising normal chaperone activity