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H 2 has antioxidant and anti-inflammatory effects, which can significantly alleviate diseases, such as ischemic brain injury, myocardial ischemiareperfusion injury, and sepsis-induced liver injury [142,143,144]

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The potential mechanisms underlying this effect include the drugs water solubility, which facilitates its passage through cell membranes, as well as its uptake via OCTs and excretion with the assistance of multidrug and toxin extrusion (MATE) proteins