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doi: 10.1016/j.mayocp.2013.02.007 8
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This process is a sign that the treatment is working, but it can be alarming
The PDE5 specific inhibitors, PDE5i, found their explosive fortune as first-line treatment for erectile dysfunction (ED), due to their powerful vasoactive properties
For example, long-term use of distal-tube diuretics such as chlortalidone may result in significant zinc depletion due to increased urinary zinc excretion (hyperzincuria) [111]
Ramkumar H
