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Statistical analysis: one-way ANOVA with Dunnetts post-test ( a, c )

Given that studies utilising BNIP3 and BAX/BAK1 have demonstrated that their inhibition or genetic deletion impacts apoptotic and necrotic markers 2,17 , it is reasonable to hypothesise that BNIP3, as a BH3-only protein activator, functions upstream of BAX and/or BAK1

In tobacco BY-2 cells, sphinganine or dihydrosphingosine (d18:0, DHS) induce a calcium dependent PCD and trigger H 2 O 2 production via the activation of NADPH oxidase(s)

[3] Differential diagnosis A series of tests are needed to identify other potential causes of the symptoms

JACC Case Rep

EMBO J 22:5293-5303
