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The prolongation of apparent half-life with multiple dosing is characteristic of drugs that undergo distribution into deep tissue compartments from which elimination is slow, creating a multi-exponential elimination profile

Soares MO, Dumville JC, Ades AE, Welton NJ (2014) Treatment comparisons for decision making: facing the problems of sparse and few data

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Tsai KL, Hsueh-Fen Chang HF, Wu SN (2013) The inhibition of inwardly rectifying K+channels by memantine in macrophages and microglial cells