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Cell 143 , 761773 (2010)

407410 Aerobic exercise may benefit the restoration of Mfn2 levels in liver mitochondria and promote fatty acid oxidation, then alleviating the symptoms of non-alcoholic fatty liver disease

This chronic activation impairs neuronal homeostasis, worsens synaptic dysfunction, and ultimately accelerates neurodegenerative processes [113116]

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PCOS is defined by the presence of reproductive and metabolic issues, which are caused and worsened by this detrimental cycle