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After the short-term combined treatment, the patient continued to take traditional treatment (orally isotretinoin) for 4 months, and the skin lesions did not recur after stopping the drug (Figures 1g, h)

Among the emerging therapeutic strategies to reduce oxidative stress in ALD, several studies have shown the beneficial effect of folate, betaine, and metadoxine administration

It also helps brighten the skin and improve blood circulation

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The optical density of the samples was detected by a microplate photometer (Multiskan GO, Thermo Fisher Scientific, Darmstadt, Germany) at a defined wavelength (405 nm
