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It is noteworthy that Metchnikoff was ahead of his time regarding the microbiome when he added, Systematic investigations should be performed on the relation of intestinal bacteria to premature aging, as well as the impact of diets that avoid intestinal putrefaction in extending life and preserving bodily functions (Metchnikoff, 1907)

[DOI] [PubMed] 246.Ren X, Yuan P, Niu J, Liu Y, Li Y, Huang L, et al

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Biomed Pharmacother 96:305312 Gill G, Blakley BW (2022) Does N-acetylcysteine improve established hearing loss in guinea pigs

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