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Your drug regimen may be adjusted over time, possibly to include a third drug and/or insulin, depending on how you respond to initial therapy

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If you are still experiencing significant nausea, vomiting, or diarrhea at the end of a 4-week dose block, stay at the current dose for another 2-4 weeks before attempting the next increase

The lack of FDA approval also means that definitive safety and efficacy trials are still forthcoming

[DOI] [PMC free article] [PubMed] [Google Scholar] 230.Rodrigues M., McBride S.W., Hullahalli K., Palmer K.L., Duerkop B.A

Further, these models provided the basis for a more detailed investigation of the biochemical mode of action of treatments using the proteomics analysis, which is a novel approach