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That plateau is important context for why stacking becomes appealing

Metro-P4 , a 4-nitroimidazole with an alkyl side chain, showed a decrease in antibiotic activity (MIC of 50 M) compared with Metro (12.5 M) 2,7 and was therefore not used in further ABPP studies

397 While some of the notable responses sparked by such heat sensing are behavioral (e.g., seeking a cooler area) or largely supracellular (vasodilation, sweating, arrector pili relaxation), 397 evidence from model organisms indicates that HSF1 signaling may be upstream and/or downstream of noncell-autonomous regulation of the HSR in heterotypic tissues (i.e., signaling between different tissues)