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A small study found that men with GSTT1 null genotypes were at an 11-fold increased risk of Parkinsons with paraquat exposure.[ref] This ties together with MAO-B the GST enzymes help combat the oxidative stress from high H2O2 levels due to MAO-B expression
However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)

Kramer, K., Dijkstra, H

(b) a transcellular pathway, mainly across the sustentacular cells, most likely by receptor-mediated endocytosis, fluid-phase endocytosis, or passive diffusion (not for peptides)
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Iron chelators, such as deferasirox, have been used in various diseases to reduce iron overload and prevent ferroptosis (222, 223)