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As the ANKIB1-RBR was not required for TLR3-SC recruitment, we next examined the role of ANKIB1s ubiquitin-interacting motif (UIM), a domain type previously reported to mediate polyubiquitin-chain binding (Extended Data Fig

Afterwards, the PROTAC is free to form a new stable ternary complex with another POI, thus exhibiting an advantageous catalytic mechanism of action (event-driven mechanism) 25

Wang et al., 2008, 2014

Thus, it provides a pragmatic direction for comparing the optimal efficiency and suitability of different plant products for broiler production in this era of antibiotic-free diet

Integrating bibliometric insights with mechanistic foundations Our bibliometric analysis shows that research on H in nephrology, though promising, has progressed irregularly since 2009, with modest publication peaks in 2019 and 2024.11,17 The field remains dominated by original research articles, whereas reviews and meta-analyses are relatively scarce,16 reflecting an emphasis on experimental or early clinical studies over comprehensive syntheses

Intermediate steps can in some sense also be seen as a way to guide the training process to make it easier