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This occurs in RPE cells and other retinal cells as well

Sabayan et al., 2012)

They are important in the processes of oncogenesis, cancer progression, drug resistance, as well as the metabolism and biosynthesis of prostaglandins, leukotrienes and steroids [17]

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Thus, the initial therapeutic hypothesis underlying anti-PD therapy involves restoring the exhaustion of PD-1 + CD8 + T cells by releasing their brakes