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When shopping for a copper peptide serum: Look for "copper tripeptide-1" or "GHK-Cu" on the INGREDIENTS label

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In a previous randomised, placebo-controlled trial, de Jager et al (2010) added metformin 850 mg three times daily to insulin therapy (a higher metformin dose than is usually now used) and demonstrated a number needed to harm of just under 14 for development of B12 deficiency over the 4.3 years of the trial

Cultures treated for 2 h (PHH, PRH, HepG2 cells with hamster S9-mix) or 4 h (HepG2 cells with rat S9-mix) with 5 mM NDMA served as positive control for sufficient metabolic activity