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This bidirectional regulation, rather than simple enhancement or inhibition, may explain BPC-157's apparent ability to promote healing in diverse pathological conditions

Therapeutic Implications Although several dietary factors, such as gluten, bile acids, fructose, ethanol, and emulsifiers are well-known agents damaging the IEB, other dietary components, such as fibers, SCFAs, glutamine, and vitamin D, may improve the IEB

In addition to increasing drug resistance to certain NAIs, multi-site mutations can sometimes produce an antagonistic effect for other NAIs

J Am Acad Dermatol 53:652659

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RAP1A: Ras-related protein Rap-1A