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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor

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Some people describe this as feeling mentally foggy or having trouble staying sharp during tasks that require attention

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Vitamin B12 is also necessary for a healthy nervous system.

This was defined as a 1-point to 2-point decline in the Revised ALS Functional Rating Scale (ALSFRS-R) total score over an initial three-month observational period