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How the four axes of cellular iron regulation described (IRE-IRP, PHD-HIF, KDM3B-mTOR-TTP, and haem-HRI) act in concert, and in different cell types across different anatomical sites and tissues where local concentrations of iron may fluctuate substantially, is unknown
Thus, this work clearly indicates that NRF2/GSH pathway plays a primary role in cisplatin resistance in lung cancer cells
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b-e , Autochthonous tumors from MMTV-PyMT Gclc f/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into mammary fat pads of wild-type C57BL/6 mice, which were treated with vehicle (corn oil
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