melanotic macule inner cheek Black pigmentation in mouth.Black pigmentation on your mucosa scary you,then must watch video Peutz-Jeghers syndrome: black spots localized
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There are sporadic somatic mutations in one of the two alleles of GNAS1 gene with mosaicism, in which the severity and specific features of the disorder depend on the number and location of cells that have mutated GNAS1
In contrast to the self-limited cows milk protein hypersensitivity of infancy, infants, and older children may develop more severe diarrhea caused by a systemic allergic reaction

The hyperpigmentation in ephelides is the result of increased sun-induced melanogenesis and transport of an increased number of fully melanized melanosomes from melanocytes to keratinocytes

Santra S, Gilkerson RW, Davidson M, Schon EA

doi: 10.3390/antiox11112133
