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It has been found that incident ARDS in trauma and sepsis patients is linked to elevated mtDNA levels in plasma ( 4.3 Implications of mtDNA in lung diseases mtDNA is a key player in the development of inflammatory lung diseases

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Broader analysis across multiple clinical trials suggests that approximately 10% of patients across all indications and doses may discontinue semaglutide due to GI complaints, which is comparable to or slightly higher than other GLP-1 receptor agonists

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