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The EFFIGACT study, a 6-month randomized controlled trial that enrolled and randomized 156 patients, showed that ACT was statistically superior to both the recommended pharmacological treatment (RPT: pregabalin + duloxetine) and the waiting list immediately after treatment, and improvements were maintained after 6 months [36, 37]

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Dry mouth (xerostomia) occurred as a TEAE in 34% and 35% of patients on pemigatinib or futibatinib, respectively (Abou-Alfa et al., 2020

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