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While the study presents promising evidence for the neuroprotective effects of hNSC-derived EVs, it also reflects broader challenges in the field, such as limited age group representation, lack of long-term follow-up, and variable methodological rigor

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These pathological changes further affect the blood circulation and vascular status of the kidney, leading to ischemia and hypoxia in various systems of the kidney and thus aggravating kidney damage [53]

doi: 10.1080/01635580802404196