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After DAA initiation, wild-type DAA-susceptible HCV species are eliminated, selecting for resistant variants

After weighing the risks, benefits and costs of existing HCV treatments and of liver biopsy, most experienced clinicians routinely obtain a liver biopsy in patients with HCV genotype 1 infection to guide recommendations for treatment (see below)

Indeed, comparative analyses of the viruses produced in hepatoma cells and in experimental models showed that the HCV produced in vivo had a lower density and a higher specific infectivity [20] and fusogenic capacity [21] than HCVcc produced in vitro

271 Bis-4-nitrophenyl phosphate (BNPP) was used to model the activity of La(III), Ce(III), Eu(III), Tb(III), and Yb(III) complexes in the presence of DOPC membranes

Some of the bile is excreted as waste, thus getting rid of excess cholesterol, but most returns to the liver and then is moved to the gall bladder for storage and use in the digestion of lipids