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The inactivation of Dnmt3a and Dnmt3b during early embryonic development hindered de novo methylation ( Dnmt1 and Dnmt3a in forebrain excitatory neurons results in long-term plasticity abnormalities in the CA1 region, accompanied by learning and memory impairments ( Dnmt1 knockout disrupts dentate gyrus development and neurogenesis (Noguchi et al., 2016)

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