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Under arsenite stress, this METTL3/YTHDF2 interaction is inhibited, which stabilizes CHAC1 mRNA and increases its expression ( In addition to arsenite-induced expression, the CHAC1 gene is transcriptionally activated during cysteine, serine or arginine depletion (Ward et al., 2024)

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Some studies in older adults have either linked lower 25-hydroxyvitamin D levels with measures of poor cognitive performance (50-53) or higher 25-hydroxyvitamin D levels with measures of better cognitive performance (54, 55)

Eat something first: food triggers the same reflex, so coffee on a full stomach often has a milder effect than coffee on an empty stomach Check what you add to it: if dairy seems to be the trigger, try less milk or a different type of milk Dont rely on decaffeinated coffee: it produces the same response, so switching wont reliably stop the effect 1 Drink water alongside it: staying hydrated supports regular, healthy digestion Cut back if your digestion is sensitive: if you live with IBS, the NHS suggests no more than 3 cups of tea, coffee, or other caffeinated drinks a day 7 Eat a diet based on whole foods rich in a variety of plant foods