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In the investigation of KRAS/LKB1/KEAP1 mutant lung adenocarcinoma cells, mild oxidative stress was observed to decrease NRF2 SUMOylation, which in turn enhanced the migration and invasion of these cells [132]

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Another study revealed that only Tg model mice exhibited a chronic inflammatory response when the hippocampal regions of 9-month-old CNS-Glud1 Tg and WT mice were examined (Wang et al., 2010)

doi:10.1186/s12885-024-13279-2

The other pump is the glutathione S-conjugate carrier which is responsible for the transport of endogenous compounds such as oxidized glutathione and leukotriene C4 as well as glutathione conjugates of foreign compounds an example of which might be S-(2,4-dinitrophenyl)glutathione

Caspr2 autoantibodies disrupt the binding of caspr2 to contactin2, potentially interfering with the clustering of VGKC ay juxtaparanodes, resulting in hyperexcitability of peripheral nerves (66)