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Gold KA, Kim ES, Liu7 DD, Yuan P, Behrens C, Solis LM, Kadara H, Rice DC, Wistuba II, Swisher SG , Lee JJ, Hong WK

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Br J Clin Pharmacol 2016

The traditional view of metabolism as a house-keeping program that sustains all cells in a uniform way has been shown as inadequate in explaining the biochemical diversity seen particularly in the immune system

Indeed, hemin-like compounds or adoptive transfer of hemin-activated macrophages reduced caerulein-induced pancreatitis, serum amylase and lipase, decreased pancreatic trypsin generation, and protected from lung injury (254), while activation of the NRF2/HO-1 pathway, through administration of Cobalt protoporphyrin IX (CoPP), induced macrophage differentiation toward a Marco hi Hmox1 hi anti-inflammatory erythrophagocytic phenotype, contributing to an overall decreased inflammatory profile in a murine model of colitis (255)

Lymphocytes multiply to fight these bacteria and enables the body free of foreign particles