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PPAR- sparing activity of another TZD, MSDC-0602, was recently shown to have attributes consistent with AMPK activation (253)

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and (5) does not affect HR in young healthy adults

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In contrast, Siwy et al [207] showed a correlation between CKD-273 and eGFR decline, but in high-risk patients treated with linagliptin a slow progression of eGFR was observed

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