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145 A complicating factor in determining metformin-induced deficiencies is that there are large vitamin B12 stores in the liver and these can take up to five years to manifest as a deficiency

For a person lacking in the vital vitamin, tinnitus may be a reality

Indications dutilisation Diminution de l'absorption de la vitamine B12 Anmie par carence en vitamine B12 chez les vgtaliens stricts Indications thrapeutiques Dficits prouvs en vitamine B 12 ds un dfaut d'absorption: maladie de Biermer, gastrectomie totale, rsection de l'ilon terminal, maladie d'Imerslund

Thus, both prophylactic and therapeutic potential is evident

The stress response is defined as a response directed against various noxious events