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The mice with Huntingtons Disease treated with withaferin A lived significantly longer, and restoration of behavioural and motor deficits was also observed, including a reduction in body weight

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Although overexpression of isoforms such as ALOX5, ALOX12, and ALOX15 can sensitize cells to ferroptosis (Yang et al., 2022), none of the isoforms has yet been proven to play a decisive role in ferroptosis

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