glutathione and excision repair Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ DNA Beyond Nucleotide Excision Repair: The

Reduces oxidative stress from free radicals

Gutzki F.-M

In turn, oxidative stress elicits nonenzymatic post-translational alterations resulting in dysfunctional proteins, the formation of danger-associated molecular patterns (DAMPs) and neo-autoantigens [15]

Available at: Accessed April 26, 2012

treatment A + B), some of the studies included in this review are not properly designed to delineate a synergistic effect (e.g., treatment A + B vs

Studies have demonstrated that the activation of JNK signaling pathway induced by MPTP/MPP + mediated-neurotoxicity and 6-OHDA lesion models in PD is involved in DA degeneration [373, 374]