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Description
IRP2 is a transcription factor sensitive to intracellular iron levels, modulating the expression of proteins related to iron and lipid metabolism, thus influencing cellular susceptibility to ferroptosis (36)

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Generally, autophagy plays a protective role in cells, but disruption of autophagy mechanisms or excessive autophagic flux usually leads to cell death

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

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Biomarkers Cancer 2, BIC.S318733
