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Studies have shown that PDC dysfunction can impair energy metabolism in the brain, leading to neurodegeneration and cognitive deficits

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We first investigated the possible association between ferroptosis signatures and MS pathology on paraffin-embedded brain tissue from SPMS patients [26]

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With more human clinical studies, our understanding can develop

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The ALDH1L1 encoded enzyme is also known as 10-formyl-THF dehydrogenase (10-FTHFDH)

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doi: 10.1016/j.immuni.2019.08.011 139 KoyamaMHippeDSSrinivasanSProllSCMiltiadousOLiNet al

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Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, et al

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