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Studies have shown that PDC dysfunction can impair energy metabolism in the brain, leading to neurodegeneration and cognitive deficits
We first investigated the possible association between ferroptosis signatures and MS pathology on paraffin-embedded brain tissue from SPMS patients [26]

With more human clinical studies, our understanding can develop

The ALDH1L1 encoded enzyme is also known as 10-formyl-THF dehydrogenase (10-FTHFDH)
doi: 10.1016/j.immuni.2019.08.011 139 KoyamaMHippeDSSrinivasanSProllSCMiltiadousOLiNet al

Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, et al
