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Anthony Didato, DMD Balanced Aesthetics + Wellness 90% of Serotonin Produced in the Gut Approximately 90% of the body's serotonin the neurotransmitter most associated with mood regulation is produced by enterochromaffin cells Cell (Yano et al., 2015) Gut-Brain Axis Bidirectional Communication The gut-brain axis describes bidirectional signaling between the enteric nervous system and central nervous system via the vagus nerve, immune Annals of Gastroenterology Leaky Gut (Intestinal Permeability) and Systemic Inflammation Increased intestinal permeability allows endotoxins (LPS) to enter the bloodstream, triggering systemic inflammatory cascades linked to anxiety, depression, brain fog, Frontiers in Immunology Overnight Fasting Improves Microbial Balance A 12-14 hour overnight fast improves microbial balance and insulin sensitivity

At Dermo Direct, we are frequently asked: What supplements can I take while on isotretinoin? Are there vitamins that help with dryness or side effects? Which supplements should I avoid? As a Dermatologist I often suggest that a lot of oral supplements are not needed whilst taking isotretinoin, as gentle skin care, emollient use and sunscreen/sun protection are the key focus areas for patients taking isotretinoin but if patients are struggling with certain side effects, some of the following supplements can help

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Almalki College of Dental Medicine, Qatar University, Doha, Qatar Sadeq Al-Maweri College of Medicine, Alfaisal University, Riyadh, Saudi Arabia Sami Almustanyir & Ziad A

Ensure you complete the dosage, as shorter treatments could cause a relapse